Natural Products Collection
Fundación MEDINA offers the possibility of licensing the use of its microbial extract collection for the search of new molecules of interest in the health, food and cosmetic areas. The collection includes different modules designed to maximize the potential and rich biodiversity present in our strains collection, and contains samples covering a wide range of microbial sources, preparation methods and chemical diversity.
Eight modules obtained using different techniques and methods of fermentation and extraction are available. These include a general module with 80.000 extracts, a module of extracts with proven antimicrobial bioactivity, a module of fractions to minimize the effect of interfering compounds, modules created from marine or halophilic bacteria, and several modules of extracts prepared with the addition of solvents, resins and chemical elicitors to the culture broths in order to induce the expression of cryptic pathways.
Click here to request more detailed information about MEDINA natural products collection (formats, extraction technology, chemical diversity, microbial sources, etc…).
Collection of Metabolite-Producing Microorganisms
Fundación MEDINA makes available for screening one of the world’s most productive collections of filamentous fungi, actinomycetes and bacteria for discovery of secondary metabolites. The collection contains some of the most important natural products discoveries of recent decades. Many strains have been the subject of natural products chemistry projects and results published on in chemistry journal or in patents (see publication list). In some cases, these strains are the sole known producers of specific secondary metabolites; some of these organisms were new to science, and therefore represent a unique chemical resource. We have a long history of international bioprospecting that have contributed to the phylogenetic scale and depth of the collection. Strains are often extensively annotated with data on metabolite distribution and prior bioactivity. Although strains are not for sale, use of specific strains can be requested under material transfer or licensing agreements.
The fungal collection has been built up since the early 1990’s and now comprises of nearly 50,000 strains. The collection is biased towards plant-associated fungi (plant parasites and symbionts, endophytes, wood and litter decomposers); furthermore, fungi from soils, dung, rock surfaces, mushrooms and lichens are well represented. Although a large portion of the collection remains uncharacterized, a significant subset has been analysed phylogenetically demonstrating the collection spans nearly all major fungal groups capable of in vitro growth.
The prokaryotic collection comprises over 60000 strains, mainly of filamentous bacteria (98%), but also of representatives of unicellular bacteria (2%). Although most are wild isolates (85%), the collection incorporates reference strains (3%) and strains from external collaborations (12%).